An adult human subject was maintained for a period of 6 months on a nearly fat-free diet less than 0. Young rats placed on the same diet developed the typical fat deficiency syndrome. The only objective clinical effects of the diet on the adult human subject were a a gradual loss of body weight during the first 3 months from 69 to 62 kg. Subjectively the most striking effects were, a disappearance of a ly experienced feeling of fatigue at the end of the day's work and b disappearance of recurrent attacks of migraine-like headache from which the subject had suffered for some years prior to the time of the present experiment.
The respiratory quotient following a large meal of the experimental diet rose to 1.
In this respect the effect of the diet on the human subject is the same as that in the rat. The iodine of the total fatty acids of the serum from fasting blood specimens was decreased from an average of before the special dietary period to an average of 93 during the period. At the same time the linoleic acid of the serum was found to have fallen from 5. These changes in the serum fatty acids are similar to those found in rats suffering from the use of diets deficient in unsaturated fatty acids Hansen and Burr, '33 and in human infants suffering from eczema Hansen, '33, '37; Brown and Hansen, ' Decrease in the unsaturated fatty acids as a result of the low-fat regimen indicates the probability that even the normal adult human subject, like the L fat mature, is unable to fabricate the highly unsaturated fatty acids, which should, therefore, be provided in the diet.
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In the light of this latter observation, it cannot be assumed that the human subject could subsist indefinitely on a diet completely devoid of the unsaturated fatty acids. Most users should in with their address. If you originally registered with a username please use that to in. Don't already have an Oxford Academic ? Oxford University Press is a department of the University of Oxford.
Low-fat diet practices of older women: prevalence and implications for dietary assessment
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George Oswald Burr. Irvine McQuarrie. Select Format Select format. Permissions Icon Permissions. Summary and Conclusions An adult human subject was maintained for a period of 6 months on a nearly fat-free diet less than 0. Issue Section:.
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